Diatom Software LLC (www.diatom.com) is a bio and healthcare informatics consultancy providing scientific software and database solutions for commercial, academic, and government clients. Our specialties are biological database design and integration, graph & network visualization, multi-objective design optimization, cloud computing, and software architecture best practices.
Some of Diatom’s recent projects include:
COMBREX (Computational Bridge to Experiments) an initiative based at Boston University to bring together computational biologists who generate predictions of gene function, and laboratory experimentalists who seek to validate those predictions in an effort to accelerate the pace of functional annotation.
CDC/NEDSS (National Electronic Disease Surveillance System). The US Centers for Disease Control and Prevention (CDC) monitors cases of about 70 different diseases occurring across our country, including Hepatitis, Chicken Pox, Measles, and various STDs. Information about each disease event is transmitted to the CDC via various messaging protocols, stored in a database, and then analyzed by CDC epidemiologists. Diatom Software, in collaboration with Brookline-based Epidemico, is working to redesign and re-implement key components of the NEDSS infrastructure in order to improve message validation, storage, analysis, and reporting.
CloudPCR (A Cloud-based system for the design of multiplex PCR assays). The Polymerase Chain Reaction (PCR) is a laboratory protocol for amplifying targets subsequences of DNA for downstream sequencing or genotyping. In Multiplex PCR, multiple DNA targets are amplified simultaneously in a single reaction tube in order to save time and reagent costs. Multiplex PCR introduces certain constraints that make the design of the assay computationally challenging, particularly as multiplexing levels increase. Diatom Software collaborated with Life Technologies / ION Torrent to develop cloud-based algorithms to design multiplex PCR experiments that could amplifying exonic DNA as a sample preparation precursor to their next-generation sequencing platform.
For more information, please contact us at (508) 429-1403, or visit our website at www.diatom.com